diff --git a/Dalamud/Interface/Internal/Windows/PluginInstaller/PluginInstallerWindow.cs b/Dalamud/Interface/Internal/Windows/PluginInstaller/PluginInstallerWindow.cs
index 560c1e61a..b2dfe445e 100644
--- a/Dalamud/Interface/Internal/Windows/PluginInstaller/PluginInstallerWindow.cs
+++ b/Dalamud/Interface/Internal/Windows/PluginInstaller/PluginInstallerWindow.cs
@@ -2581,26 +2581,32 @@ internal class PluginInstallerWindow : Window, IDisposable
 
         if (localPlugin is LocalDevPlugin plugin)
         {
+            var isInDefaultProfile =
+                Service<ProfileManager>.Get().IsInDefaultProfile(localPlugin.Manifest.InternalName);
+
             // https://colorswall.com/palette/2868/
             var greenColor = new Vector4(0x5C, 0xB8, 0x5C, 0xFF) / 0xFF;
             var redColor = new Vector4(0xD9, 0x53, 0x4F, 0xFF) / 0xFF;
 
             // Load on boot
-            ImGui.PushStyleColor(ImGuiCol.Button, plugin.StartOnBoot ? greenColor : redColor);
-            ImGui.PushStyleColor(ImGuiCol.ButtonHovered, plugin.StartOnBoot ? greenColor : redColor);
-
-            ImGui.SameLine();
-            if (ImGuiComponents.IconButton(FontAwesomeIcon.PowerOff))
+            using (ImRaii.Disabled(!isInDefaultProfile))
             {
-                plugin.StartOnBoot ^= true;
-                configuration.QueueSave();
-            }
+                ImGui.PushStyleColor(ImGuiCol.Button, plugin.StartOnBoot ? greenColor : redColor);
+                ImGui.PushStyleColor(ImGuiCol.ButtonHovered, plugin.StartOnBoot ? greenColor : redColor);
 
-            ImGui.PopStyleColor(2);
+                ImGui.SameLine();
+                if (ImGuiComponents.IconButton(FontAwesomeIcon.PowerOff))
+                {
+                    plugin.StartOnBoot ^= true;
+                    configuration.QueueSave();
+                }
 
-            if (ImGui.IsItemHovered())
-            {
-                ImGui.SetTooltip(Locs.PluginButtonToolTip_StartOnBoot);
+                ImGui.PopStyleColor(2);
+
+                if (ImGui.IsItemHovered())
+                {
+                    ImGui.SetTooltip(isInDefaultProfile ? Locs.PluginButtonToolTip_StartOnBoot : Locs.PluginButtonToolTip_NeedsToBeInDefault);
+                }
             }
 
             // Automatic reload
diff --git a/Dalamud/Plugin/Internal/PluginManager.cs b/Dalamud/Plugin/Internal/PluginManager.cs
index c382ce3d8..781732776 100644
--- a/Dalamud/Plugin/Internal/PluginManager.cs
+++ b/Dalamud/Plugin/Internal/PluginManager.cs
@@ -862,10 +862,17 @@ Thanks and have fun!";
             var devPlugin = new LocalDevPlugin(dllFile, manifest);
             loadPlugin &= !isBoot || devPlugin.StartOnBoot;
 
-            // If we're not loading it, make sure it's disabled
-            // NOTE: Should be taken care of below by the profile code
-            // if (!loadPlugin && !devPlugin.IsDisabled)
-            //     devPlugin.Disable();
+            var probablyInternalNameForThisPurpose = manifest?.InternalName ?? dllFile.Name;
+            var wantsInDefaultProfile =
+                this.profileManager.DefaultProfile.WantsPlugin(probablyInternalNameForThisPurpose);
+            if (wantsInDefaultProfile == false && devPlugin.StartOnBoot)
+            {
+                this.profileManager.DefaultProfile.AddOrUpdate(probablyInternalNameForThisPurpose, true, false);
+            }
+            else if (wantsInDefaultProfile == true && !devPlugin.StartOnBoot)
+            {
+                this.profileManager.DefaultProfile.AddOrUpdate(probablyInternalNameForThisPurpose, false, false);
+            }
 
             plugin = devPlugin;
         }